Relationship between single nucleotide polymorphisms of paraoxonase 2 and stroke / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between single nucleotide polymorphisms of paraoxonase 2 (PON2) and stroke.</p><p><b>METHODS</b>Objects examined comprised of three groups 120 healthy people, 150 patients with cerebral hemorrhage, 180 patients with cerebral infarction. The PON2 genotypes were determined with PCR and digested by specific restriction enzymes.</p><p><b>RESULTS</b>C311S and G148A polymorphisms of PON2 gene existed among population of Chinese Hunan area, with the allele frequencies 0.23/0.77 for C/S and 0.57/0.43 for G/A in the control group. There was no significant difference of genotype and allele frequency between stroke patients and controls (P>0.05).</p><p><b>CONCLUSION</b>C311S polymorphism of PON2 has no significant correlation with stroke in Han people of Chinese Hunan area and allele C/S is not an independent risk factor for stroke,neither is G148A.</p>