Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 213-216, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-247349
ABSTRACT
<p><b>OBJECTIVE</b>To investigate two single nucleotide polymorphism sites of T cell immunoglobulin domain and mucin domain protein-4 (TIM4) and to detect their relationship with allergic asthma in a population of Hans from Hubei province of China.</p><p><b>METHODS</b>The polymorphisms (8570G > A and 11515C > A) were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 145 cases of allergic asthma and 130 healthy controls. The genotype and allele frequencies were calculated and analyzed.</p><p><b>RESULTS</b>The genotype frequencies of GG, GA and AA in 8570G > A polymorphism were 0.985, 0.015 and 0 respectively in the healthy population and 0.931, 0.069 and 0 respectively in the allergic asthma population. There was significant difference in genotype and allele frequencies between the allergic asthma patients and control subjects (P=0. 030, P=0.032). The polymorphism of 11515C>o A was not detected.</p><p><b>CONCLUSION</b>The polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Asma
/
Polimorfismo de Longitud del Fragmento de Restricción
/
China
/
Reacción en Cadena de la Polimerasa
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Etnología
/
Frecuencia de los Genes
/
Genética
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Artículo
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