Your browser doesn't support javascript.
loading
Research methods of anti-HIV-1 inhibitors targeting at Vif-APOBEC3G axis / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 806-809, 2011.
Artículo en Chino | WPRIM | ID: wpr-247382
ABSTRACT
The mammalian APOBEC3G protein (apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 protein G, APOBEC3G) is an important component of the cellular innate immune response to retroviral infection. APOBEC3G can extinguish HIV-1 (human immunodeficiency virus type 1) infectivity by its incorporation into virus particles and subsequent cytosine deaminase activity to block replication of HIV-1. HIV-1 Vif (viral infectivity factor) suppresses various APOBEC3 proteins through a common mechanism which induces the degradation of target proteins. Therefore, the interrelation of Vif-APOBEC3G has been extensively studied, which represents attractive targets for the development of novel inhibitors. We summarize the papers in which the detection technique and methods have been developed to assay the anti-HIV activity and its mechanism, such as western-blotting, co-immunoprecipitation, pulse-chase experiments, bioluminescence resonance energy transfer, biomolecular interaction analysis. This review is towards developing therapeutics aimed at the Vif-APOBEC3G axis.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Western Blotting / VIH-1 / Fármacos Anti-VIH / Resonancia por Plasmón de Superficie / Citidina Desaminasa / Inmunoprecipitación / Productos del Gen vif del Virus de la Inmunodeficiencia Humana / Fluorescencia / Desaminasa APOBEC-3G Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2011 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Western Blotting / VIH-1 / Fármacos Anti-VIH / Resonancia por Plasmón de Superficie / Citidina Desaminasa / Inmunoprecipitación / Productos del Gen vif del Virus de la Inmunodeficiencia Humana / Fluorescencia / Desaminasa APOBEC-3G Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2011 Tipo del documento: Artículo