Association between Beta Adrenergic Receptor Polymorphism and Ischemic Stroke: A Meta-Analysis / 대한뇌졸중학회지
Journal of Stroke
;
: 138-143, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-24747
ABSTRACT
BACKGROUND AND PURPOSE:
The purpose of this meta-analysis was to determine the precise association between beta-2 adrenergic receptor (beta2AR) polymorphism and Ischemic stroke.METHODS:
Published case control studies on association between beta2AR and ischemic stroke were searched from electronic databases. Pooled Odds ratio and 95% Confidence interval were calculated by using software RevMan version 5.2.RESULTS:
A total of three studies involving 1,642 cases and 1,673 controls, which were published from 2007 to 2014, were subjected to meta-analysis for allelic association and 518 cases and 510 controls for genotypic association. Pooled analysis of two studies for genotypic association suggested that subjects carrying Gln27Glu polymorphism of beta2AR had an increased risk for Ischemic stroke under recessive model (OR 2.09; 95% CI; 1.20 to 3.64) and under dominant model (OR 1.47; 95% CI 1.14 to 1.90). Pooled analysis of three studies for allelic association showed a significantly higher Glu27 allele of beta2AR in the patients with ischemic stroke (OR 1.58; 95% CI; 1.38 to 1.81).CONCLUSIONS:
The present meta-analysis suggests that Gln27Glu polymorphism of beta2AR gene is associated with increased risk for ischemic stroke.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estudios de Casos y Controles
/
Oportunidad Relativa
/
Infarto Cerebral
/
Receptores Adrenérgicos
/
Receptores Adrenérgicos beta 2
/
Accidente Cerebrovascular
/
Alelos
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Stroke
Año:
2015
Tipo del documento:
Artículo
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