Sample size requirements for association studies on gene-gene interaction in case-control study / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 623-626, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-247505
ABSTRACT
<p><b>OBJECTIVE</b>Sample size requirements for association studies on gene-gene interaction in case-control study.</p><p><b>METHODS</b>Selecting different parameters (such as inheritance mode, susceptibility frequency, frequency of allele for disease, OR of gene main effect) and infilling them into QUANTO software based on conditional logistic regression mode.</p><p><b>RESULTS</b>(1) The main parameters influencing the sample size requirements were the levels of interaction between genes and the susceptibility frequency. The numbers of sample were the same between recessive and dominant when susceptibility frequency were the same. (2) Sample size for testing of gene-gene interaction was different from that for testing of genetic effects.</p><p><b>CONCLUSION</b>It was convenient to use the numbers of sample size from the results for gene-gene interaction in case-control study.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proyectos de Investigación
/
Marcadores Genéticos
/
Estudios de Casos y Controles
/
Modelos Logísticos
/
Factores de Riesgo
/
Sensibilidad y Especificidad
/
Tamaño de la Muestra
/
Carácter Cuantitativo Heredable
/
Predisposición Genética a la Enfermedad
/
Frecuencia de los Genes
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2004
Tipo del documento:
Artículo
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