Effect of Allopurinol on Methylmercuric Chloride in Cultured O1igodendrocytes / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 183-188, 1996.
Artículo
en Coreano
| WPRIM
| ID: wpr-24808
ABSTRACT
To elucidate the neurotoxic mechanism of methylmercury on cultured bovine oligodendrocytes, neurotoxic effect was estimated by MTT assay after cultures were exposed to various concentrations of methylmercuric chloride (MMC). In addition, neuroprotective effect of antioxidant, allopurinol agonist MMC-induced neurotoxicity was examined on these cultures. Exposure of cultured bovine oligodendrocytes to MMC showed less than 50% of the cell viability 24 hours after treatment with 35µM of MMC. And also, allopurinol blocked the neurotoxicity induced by MMC on these cultures. These results suggest that oxygen radicals involve in MMC-mediated neurotoxicity, and also seletive antioxidants such as allopurinol are effective in blocking the neurotoxicity induced by MMC on cultured bovine oligodendrocytes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Supervivencia Celular
/
Oligodendroglía
/
Alopurinol
/
Especies Reactivas de Oxígeno
/
Fármacos Neuroprotectores
/
Antioxidantes
Idioma:
Coreano
Revista:
Korean Journal of Physical Anthropology
Año:
1996
Tipo del documento:
Artículo
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