Study on a new point mutation of nt3426 A --> G of mitochondrial DNA in a diabetes mellitus family / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 235-237, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-248451
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the relationship between point mutations of nt3243A --> G, nt3426 A --> G of mitochondrial DNA and type 2 diabetes mellitus(DM).</p><p><b>METHODS</b>Two hundred patients with type 2 DM and 180 controls with normal glucose tolerance and absence of DM family history were included. The mutations were determined by PCR-restriction fragment length polymorphism.</p><p><b>RESULTS</b>The point mutation nt3426A --> G of mitochondrial DNA ND1 was found in 2 of the patients with type 2 DM (1.0%) but in none of the controls (0). The incidence of this mutation showed no significant difference between the two groups(P>0.05). And none was found to have the mutation of nt3243 --> G.</p><p><b>CONCLUSION</b>The point mutation nt3426 A --> G of mitochondrial DNA ND1 may not be an independent factor to cause type 2 DM.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linaje
/
ADN Mitocondrial
/
Familia
/
Reacción en Cadena de la Polimerasa
/
Mutación Puntual
/
Diabetes Mellitus Tipo 2
/
Genética
Límite:
Adulto
/
Anciano
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2003
Tipo del documento:
Artículo
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