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Association of coagulation factor V, VII gene polymorphisms with coronary heart disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 39-42, 2003.
Artículo en Chino | WPRIM | ID: wpr-248505
ABSTRACT
<p><b>OBJECTIVE</b>To study the distribution of coagulation factor V(FV), VII(FVII) gene polymorphisms in Chinese Han population and the association of the polymorphisms with coronary heart disease(CHD).</p><p><b>METHODS</b>Genotypes of FV FVII were typed in 234 CHD patients and 210 controls by polymerase chain reaction-restriction fragment length polymorphism. Selected coronary angiography was performed in 234 CHD patients.</p><p><b>RESULTS</b>FVII allelic frequencies of R,Q and H7,H6 were 94.6%, 5.6%, 70.3%, 29.7% and 91.9%, 8.1%, 60.9%, 39.1% in CHD group and control group respectively. Genotype distribution was in accordance with Hardy-Weinberg equilibrium. There was no significant difference in frequencies of allele and genotype in R353Q or HVR4 polymorphisms between CHD group and control group. The distribution of allele and genotype in R353Q was of significant difference between non-myocardial infarction subgroup and myocardial infarction subgroup (chi2 = 4.711, P<0.05, OR=0.37,95% CI 0.15-0.94). However, HVR4 polymorphism was not found to be of significant difference within two group (chi2 = 0.142, P>0.05). There was no FV Leiden mutation in all the CHD patients and normal controls.</p><p><b>CONCLUSION</b>The Q allele of the R353Q polymorphism of the FVII gene may be a protective factor against myocardial infarction.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Polimorfismo Genético / ADN / Factor V / Factor VII / China / Reacción en Cadena de la Polimerasa / Enfermedad Coronaria / Frecuencia de los Genes / Genética Límite: Anciano / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Polimorfismo Genético / ADN / Factor V / Factor VII / China / Reacción en Cadena de la Polimerasa / Enfermedad Coronaria / Frecuencia de los Genes / Genética Límite: Anciano / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2003 Tipo del documento: Artículo