Association study of heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 499-501, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-248519
ABSTRACT
<p><b>OBJECTIVE</b>To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene.</p><p><b>METHODS</b>Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls.</p><p><b>RESULTS</b>Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017).</p><p><b>CONCLUSION</b>The results suggested that liability to heroin-dependence was associated with -287 A/G polymorphism of COMT gene.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN
/
Enzimas de Restricción del ADN
/
Catecol O-Metiltransferasa
/
Polimorfismo de Nucleótido Simple
/
Alelos
/
Frecuencia de los Genes
/
Genética
/
Genotipo
/
Dependencia de Heroína
/
Metabolismo
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2002
Tipo del documento:
Artículo
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