Your browser doesn't support javascript.
loading
Immune responses induced by recombinant adenovirus Ad5F35-LMP2 in rhesus monkeys / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 226-228, 2007.
Artículo en Chino | WPRIM | ID: wpr-248796
ABSTRACT
<p><b>OBJECTIVE</b>To observe the specific cellular and humoral immune responses after immunization with recombinant adenovirus Ad5F35-LMP2 in rhesus monkeys.</p><p><b>METHODS</b>Sixteen rhesuses were immunized with Ad5F35-LMP2 through intra-muscular injection in three groups high dosage group (1.5 x 10(10) TCID(50)/rhesus), medium dosage group (1.5 x 10(9)TCID(50)/rhesus), low dosage group (1.5 x 10(8)TCID50/rhesus) and the last group was control (PBS 4 ml/rhesus). They were totally immunized three times at intervals of one month. The EBV-LMP2 specific cellular immune responses were tested during the 0, 4, 8, 12 weeks by Elispot after immunization respectively. And the titers of anti-LMP2 antibody were tested by EIA at the same time.</p><p><b>RESULTS</b>EBV-LMP2 specific cellular and humoral immune responses which were induced by recombinant adenovirus Ad5F35-LMP2 can be found in all the three dosage groups. The potency of immune responses was related with the dosage of immunization. Higher dosage elicited more potent immune response.</p><p><b>CONCLUSION</b>The recombinant adenovirus Ad5F35-LMP2 could elicit LMP2 specific cellular and humoral immune responses in rhesus.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proteínas Recombinantes de Fusión / Diferenciación Celular / Adenovirus Humanos / Proteínas de la Matriz Viral / Inmunización / Herpesvirus Humano 4 / Alergia e Inmunología / Genética / Inmunidad Celular / Macaca mulatta Límite: Animales Idioma: Chino Revista: Chinese Journal of Experimental and Clinical Virology Año: 2007 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proteínas Recombinantes de Fusión / Diferenciación Celular / Adenovirus Humanos / Proteínas de la Matriz Viral / Inmunización / Herpesvirus Humano 4 / Alergia e Inmunología / Genética / Inmunidad Celular / Macaca mulatta Límite: Animales Idioma: Chino Revista: Chinese Journal of Experimental and Clinical Virology Año: 2007 Tipo del documento: Artículo