Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 165-167, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-248814
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of bicyclol for chronic hepatitis B.</p><p><b>METHOD</b>The authors searched CBMDisk, CJFD (2000-2006), CJD-CD, PubMed (1966-2006) for randomized controlled trials (RCT) comparing bicyclol versus non-antiviral interventions, interferon alpha (IFN-a) and lamivudine for treatment of chronic hepatitis B. Two reviewers performed data extraction and quality assessment independently and discussed when there was different opinion. We analyzed the data with RevMan 4.2 software supplied by Cochrane Collabration.</p><p><b>RESULTS</b>Fourteen RCTs involving 1782 patients were included. ALT recovery rate of bicyclol group was 69.3 percent while that of the control group was 59.0 percent, the difference was statistical significant [RR 1.24, 95 percent CI (1.01, 1.52), P=0.04]. Loss of HBeAg in the bicyclol group (22.1 percent) was higher than that of the control group (13.5 percent) [RR 1.65, 95 percent CI (1.32, 2.06), P<0.00001]. No serious adverse events were reported.</p><p><b>CONCLUSION</b>Bicyclol might be beneficial to recovery of liver function and loss of serum HBV marker. However, more high quality clinical trials are needed for confirmation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Compuestos de Bifenilo
/
Ensayos Clínicos Controlados Aleatorios como Asunto
/
Virus de la Hepatitis B
/
Hepatitis B Crónica
/
Quimioterapia
Tipo de estudio:
Ensayo Clínico Controlado
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2007
Tipo del documento:
Artículo
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