Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 533-535, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-249777
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of TGF-alpha gene polymorphism and non-syndromic cleft lip with cleft palate in Shandong province.</p><p><b>METHODS</b>Polymerase chain reaction combined with restrict enzyme digestion was used to detect the target gene variation in 98 patients with non-syndromic cleft lip with cleft palate and 101 healthy controls.</p><p><b>RESULTS</b>The C2 allele frequency in patients with non-syndromic cleft lip with cleft palate was significantly higher than that in healthy controls. The genotype frequency in patients with positive family history was significantly higher than that without positive family history.</p><p><b>CONCLUSION</b>TGF-alpha gene polymorphism is closely associated with non-syndromic cleft lip with cleft palate in Shandong, especially in patients with positive family history.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Reacción en Cadena de la Polimerasa
/
Factor de Crecimiento Transformador alfa
/
Labio Leporino
/
Fisura del Paladar
/
Frecuencia de los Genes
/
Genotipo
Límite:
Humanos
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2006
Tipo del documento:
Artículo
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