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Inhibition of hepatitis B virus replication by RNA interference in vitro / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 522-525, 2004.
Artículo en Chino | WPRIM | ID: wpr-250168
ABSTRACT
<p><b>OBJECTIVE</b>To design pSilencer3.1-H1hygro plasmid expressing short interfering RNAs (siRNA) that targets HBV core gene region, and to evaluate inhibitory effect of this siRNA on HBV in vitro.</p><p><b>METHODS</b>HepG2 2.2.15 was used as target cells. The plasmid and liposome metafectene were cotransfected into the cultured cells, HBV DNA were analyzed by fluorogenic quantitative PCR (FQ-PCR), HBV C-mRNA was detected by semi-quantitative RT-PCR.</p><p><b>RESULTS</b>The plasmid expressing siRNA was successfully constructed. The two constructed siRNAs could effectively inhibit HBV replication, and their inhibitive effect on HBV was dose-dependent.</p><p><b>CONCLUSION</b>These results showed that siRNA could substantially inhibit HBV replication in the infected cells</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Virología / Replicación Viral / Células Tumorales Cultivadas / Virus de la Hepatitis B / Interferencia de ARN / Genética / Neoplasias Hepáticas Límite: Humanos Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Virología / Replicación Viral / Células Tumorales Cultivadas / Virus de la Hepatitis B / Interferencia de ARN / Genética / Neoplasias Hepáticas Límite: Humanos Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2004 Tipo del documento: Artículo