Cellular immunotoxicity of rAAV gene medicine and possible solutions / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1071-1077, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-250569
ABSTRACT
Gene medicine based on recombinant adeno-associated virus (rAAV) vector has rapidly become the prior-choose reagent for gene therapy, since it had been shown that the rAAV was able to stably express many genes in vivo without detectable side-effect. However, recent findings of CTL immune responses to AAV capsid in a clinical trial highlighted a new issue regarding safety that previously was not identified in animal studies. Obviously it is so important to understand the interaction of rAAV with the immune system in details for the safety and success of rAAV gene medicine. In this review we evaluate several current hypotheses aiming to explain the cellular immunotoxicity, also analysis the current findings including the presentation kinetics of the capsid antigen and the activation of CTL. Focusing on the key steps of the immune response several solutions are proposed, including immunosuppression, optimization of vector and improvement of purity, in order to insure clinical safety and efficacy of rAAV.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Proteínas Recombinantes
/
Linfocitos T Citotóxicos
/
Terapia Genética
/
Cápside
/
Dependovirus
/
Complejo de la Endopetidasa Proteasomal
/
Alergia e Inmunología
/
Inhibidores de Proteasoma
/
Vectores Genéticos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2010
Tipo del documento:
Artículo
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