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Antiviral activities of cycloheximide and its derivatives / 药学学报
Acta Pharmaceutica Sinica ; (12): 268-273, 2010.
Artículo en Chino | WPRIM | ID: wpr-250631
ABSTRACT
Cycloheximide (CHX) inhibits protein synthesis in most eukaryotic cells and it is a well-known tool commonly used in biochemical research. In this paper, the antiviral spectrum of CHX against several DNA and RNA viruses have been evaluated. CHX showed strong inhibitory activities against several RNA viruses such as HIV-1, influenza viruses, coxsackie B virus, enterovirus (EV71) and several DNA viruses such as HSV and HCMV. Especially the strong inhibitory activities of CHX against coxsackie B virus and enterovirus caught our attention, since effective drugs available in clinic are limited. The SAR of CHX derivatives also has been discussed in the paper. The hydroxyl group at C-2' and carbonyl group at C-2" of CHX are essential for its antiviral activity. And modification to these groups results its derivatives' antiviral activities reduced or lost.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Antivirales / Farmacología / Virus ARN / Línea Celular / Química / Enterovirus / Enterovirus Humano B / Cicloheximida / Virus ADN Límite: Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Antivirales / Farmacología / Virus ARN / Línea Celular / Química / Enterovirus / Enterovirus Humano B / Cicloheximida / Virus ADN Límite: Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2010 Tipo del documento: Artículo