HIV entry inhibitors: progress in development and application / 药学学报
Acta Pharmaceutica Sinica
;
(12): 131-140, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-250660
ABSTRACT
This review discusses recent progress in the development of anti-HIV agents, with emphasis on small molecule HIV-1 entry inhibitors. The entry inhibitors primarily target HIV-1 envelope glycoproteins or the cellular receptors, CD4 and chemokine receptors. Two of the entry inhibitors, enfuvirtide and maraviroc, have been approved by the US FDA for AIDS therapy. The drug resistance associated with some of the entry inhibitors will also be discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fragmentos de Péptidos
/
Farmacología
/
Fisiología
/
Triazoles
/
Estructura Molecular
/
Antígenos CD4
/
Proteína gp41 de Envoltorio del VIH
/
Proteína gp120 de Envoltorio del VIH
/
Infecciones por VIH
/
Química
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Pharmaceutica Sinica
Año:
2010
Tipo del documento:
Artículo
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