Expression of integrin-beta1 in oral leukoplakia and early invasive carcinoma and its relationship with cell proliferation / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 608-611, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-250989
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression and significance of integrin-beta1 in oral leukoplakia and early invasive carcinoma.</p><p><b>METHODS</b>The expression of integrin-beta1 and Ki-67 was examined in 12 normal oral mucosa, 10 simple hyperplasia, 24 epithelial dysplasia and 14 early invasive carcinoma by immunohistochemistry.</p><p><b>RESULTS</b>In normal and simple hyperplasia epithelium, integrin-beta1 was mostly expressed in the basal cell membrane, and Ki-67 in the nuclei of basal and the parabasal layers. In dysplasia epithelium and early invasive carcinoma, integrin-beta1 showed membrane staining and Ki-67 showed nuclear staining in dysplastic basal cells, sprinkle cells and SCC cells. Integrin-beta1 and Ki-67 were overexpressed in 7 and 10 of 24 dysplasia cases and in 8 of 14 early invasive carcinoma cases respectively. There was a significant difference in integrin-beta1 and Ki-67 expression among the four groups (chi2 = 10.651, P = 0.014; chi2 = 14.831, P = 0.002), in integrin-beta1 expression among normal oral mucosa, simple hyperplasia and early invasive carcinoma (P = 0.008, P = 0.013) and in Ki-67 expression among normal oral mucosa and dysplasia, early invasive carcinoma (P = 0.026, P = 0.001), and among simple hyperplasia and early invasive carcinoma (P = 0.005). A significant correlation between integrin-beta1 and Ki-67 (R = 0.442, P < 0.01) was found.</p><p><b>CONCLUSIONS</b>Integrin-beta1 showed increased staining in dysplasia epithelium cells and SCC cells, and may correlate to the proliferation of the dysplasia cells.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Leucoplasia Bucal
/
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Integrina beta1
/
Antígeno Ki-67
/
Proliferación Celular
/
Metabolismo
/
Mucosa Bucal
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2008
Tipo del documento:
Artículo
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