Effect of surfactants on the in vitro and in vivo properties of amphotericin B liposome / 药学学报
Acta Pharmaceutica Sinica
;
(12): 471-474, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-251058
ABSTRACT
<p><b>AIM</b>Some surfactants such as DSPE-PEG, Tween 80 and Brij 35 were used to modify the amphotericin B liposome, improve the stability, optimize the tissue distribution and decrease the toxicity of amphotericin B liposome.</p><p><b>METHODS</b>The amphotericin B liposome was prepared by the film-supersound method. The effects of cholesterol and amphotericin B on the encapsulation percentage were studied. The diameter, leakage percentage in phosphate buffer solution(PBS) and calf blood serum, and tissue distributions of amphotericin B liposome in the rat were determined.</p><p><b>RESULTS</b>The top encapsulation percentage of amphotericin B liposome is (91.2 +/- 1.6)%. After modification with DSPE-PEG, Tween 80 and Brij 35, the encapsulation percentages were improved, the average diameters were decreased and the stabilities were improved, the amphotericin B concentrations in the liver, spleen and kidney were decreased, and the amphotericin B concentrations in the brain were increased, especially in the AmB-L-Tween 80 group.</p><p><b>CONCLUSION</b>DSPE-PEG and Brij 35 could decrease the clearing of reticuroendothelial systems(RES) to the amphotericin B liposome and Tween 80 could facilitate the transporting of amphotericin B liposome into the brain.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de la Partícula
/
Farmacología
/
Fosfatidiletanolaminas
/
Polietilenglicoles
/
Polisorbatos
/
Tensoactivos
/
Encéfalo
/
Portadores de Fármacos
/
Farmacocinética
/
Distribución Tisular
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2003
Tipo del documento:
Artículo
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