Studies on structure modification of (+)-praeruptorin A / 药学学报

ABSTRACT

<p><b>AIM</b>In order to look for new active compounds, the structure of (+)-praeruptorin A is modified.</p><p><b>METHODS</b>(+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out.</p><p><b>RESULTS</b>Eighteen compounds were semi-synthesized from (+)-praeruptorin A.</p><p><b>CONCLUSION</b>Fourteen compounds (5-18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show calcium antagonist activity, but they are not as strong as (+)-praeruptorin A.</p>