Synthesis and antibacterial activity of 7-(4-acylamino-thiocarbamoyl-1-piperazinyl) fluoroquinolone analogues in vitro / 药学学报
Acta Pharmaceutica Sinica
;
(12): 264-267, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-251128
ABSTRACT
<p><b>AIM</b>To synthesize new fluoroquinolone analogues as antibacterial compounds.</p><p><b>METHODS AND RESULTS</b>By reaction of acryl chloride(chloro-carbonic ester) with sodium sulfocyanate, acyl isosulfocyanic ester were easily obtained. Twelve 7-(4-acylamino-thiocarbamoyl-1-piperazinyl) fluoroquinolone analogues (1-12) were synthesized through modifying the 7-piperazine of norflorxacin and ciprofloxacin with isosulfocyanic ester synthesized above. The structures of synthesized compounds were characterized by 1HNMR, IR and elemental analysis.</p><p><b>CONCLUSION</b>Antibacterial activities of the new compounds were evaluated in vitro compared with norflorxacin. Compounds 5, 7, 10 and 12 showed antibacterial activities.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Bacillus subtilis
/
Estructura Molecular
/
Ciprofloxacina
/
Pruebas de Sensibilidad Microbiana
/
Norfloxacino
/
Química
/
Técnicas Químicas Combinatorias
/
Fluoroquinolonas
/
Escherichia coli
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS