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Alternative splicing in 5'-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines
Experimental & Molecular Medicine ; : 193-196, 2000.
Artículo en Inglés | WPRIM | ID: wpr-25124
ABSTRACT
Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and, execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there are three forms of STK-15 gene in breast cancer cell lines. Alternative splice positions are located in 5'-untranslated region of STK15 gene. The results of in vitro translation experiments revealed that the alternative splicing in the 5'-untranslated region of STK15 had no effect on protein translation. The differential expression patterns of these alternatively spliced STK15 in breast cell lines and primary tumors therefore suggest that STK15 gene transcription may be differentially regulated or stabilized in these cells.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Mama / Datos de Secuencia Molecular / Células Tumorales Cultivadas / Secuencia de Bases / Proteínas Serina-Treonina Quinasas / Empalme Alternativo / Centrosoma / Regiones no Traducidas 5' Límite: Femenino / Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Mama / Datos de Secuencia Molecular / Células Tumorales Cultivadas / Secuencia de Bases / Proteínas Serina-Treonina Quinasas / Empalme Alternativo / Centrosoma / Regiones no Traducidas 5' Límite: Femenino / Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2000 Tipo del documento: Artículo