Aberrant DNA methylation in human cancers / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 798-804, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-251391
ABSTRACT
DNA methylation, one of the best-characterized epigenetic modifications, plays essential roles in diseases, including human cancers. In recent years, our understanding on DNA methylation with human cancers has made significant progress, which was facilitated by stunning development in the analysis of the human methylome of multiple cancer types. In this review, recent developments in the characterization of aberrant DNA methylation involved in human cancers development were discussed with special emphasis on the mechanisms of aberrant DNA methylation in human cancers. We also summarize the recent treatment strategy for human cancers with de-methylation drugs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Genoma Humano
/
Metilación de ADN
/
Epigénesis Genética
/
Genética
/
Metabolismo
/
Neoplasias
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Año:
2013
Tipo del documento:
Artículo
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