Synthesis and anti-tumor activity of oleanolic acid derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 469-474, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-251755
ABSTRACT
Thirteen novel oleanolic acid (OA) derivatives were designed and synthesized with modification at positions of C-3, C-12 and C-28 of OA. Their structures were confirmed by MS, 1H NMR and elemental analysis. Their in vitro cytotoxicities against various cancer cell lines (SGC7901, MCF-7 and A549) were evaluated by MTT assay. The results indicated that the tested derivatives were found to have stronger cell growth inhibitory activity than OA. Among them, compounds II2 and II3 showed more potent cytotoxicity on MCF-7 and A549 tumor cells than gefitinib (positive control). They are worthy to be studied further.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácido Oleanólico
/
Farmacología
/
Diseño de Fármacos
/
Línea Celular Tumoral
/
Proliferación Celular
/
Antineoplásicos Fitogénicos
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
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