Role of Nrf2 in neurodegenerative diseases and recent progress of its activators / 药学学报
Acta Pharmaceutica Sinica
;
(12): 375-384, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-251768
ABSTRACT
The nuclear factor erythroid 2 related factor 2 (Nrf2) is a key protein of endogenous antioxidant defense systems in the body. In response to oxidative stress, Nrf2 translocates to nucleus and binds to antioxidant response elements (ARE), regulating the expression of a large amounts of antioxidant genes and maintaining a proper redox balance. The pathological processes of neurodegenerative diseases are associated with generation of reactive oxygen species, which cause oxidative stress. Oxidative stress plays a cardinal role in the onset and progression of neurodegenerative diseases. Nrf2-inducer compounds can reduce oxidant stress and have shown therapeutic efficacy in many neurodegenerative disease models. How to activate the Nrf2 signaling pathway effectively has been received much attention. Here we provided an overview of specific mechanism of Nrf2-ARE pathway and the protective effects of Nrf2 in different neurodegenerative diseases, and summarized the Nrf2 activators recently in preclinical study.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Transducción de Señal
/
Especies Reactivas de Oxígeno
/
Estrés Oxidativo
/
Enfermedades Neurodegenerativas
/
Factor 2 Relacionado con NF-E2
/
Metabolismo
/
Antioxidantes
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS