Design, synthesis and anti-platelet aggregation activities of ligustrazine-tetrahydroisoquinoline derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 326-331, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-251776
ABSTRACT
Abstract Fifteen novel ligustrazine-tetrahydroisoquinoline derivatives were designed and synthesized according to the association principle of pharmaceutical chemistry. The structures were identified by IR, NMR and ESI-MS. The inhibitory activities of platelet aggregation induced by ADP and AA have been measured by Bron method. Preliminary pharmacological results showed that compounds 7g, 7h and 7n had potent inhibitory activity against platelet aggregation induced by AA, and the compound 7o showed significant inhibitory activity against platelet aggregation induced by ADP.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pirazinas
/
Inhibidores de Agregación Plaquetaria
/
Diseño de Fármacos
/
Química
/
Agregación Plaquetaria
/
Tetrahidroisoquinolinas
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS