Research progress of p70 ribosomal protein S6 kinase inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 261-271, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-251785
ABSTRACT
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade. The p70 ribosomal protein S6 kinase is closely associated with diverse cellular processes such as protein synthesis, mRNA processing, glucose homeostasis, cell growth and apoptosis. Recent studies have highlighted the important role of S6K in cancer, which arose interests of scientific researchers for the design and discovery of anti-cancer agents. Herein, the mechanisms of S6K and available inhibitors are reviewed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Química
/
Proteínas Quinasas S6 Ribosómicas 70-kDa
/
Inhibidores de Proteínas Quinasas
/
Serina-Treonina Quinasas TOR
/
Metabolismo
/
Antineoplásicos
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
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