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Design, synthesis and evaluation of 5-aminobenzimidazolone derivatives as acetylcholinesterase inhibitors / 药学学报
Acta Pharmaceutica Sinica ; (12): 64-69, 2015.
Article en Zh | WPRIM | ID: wpr-251816
Biblioteca responsable: WPRO
ABSTRACT
The target compounds were prepared from 5-aminobenzimidazolone by two steps reaction, and their AChE inhibitory activities were measured by Ellman method in vitro. The AChE inhibitory activity of compound 4d is the best of them, and its IC50 value is equal to 7.2 μmol·L(-1), which is better than that of rivastigmine; moreover the 4d had no inhibitory activities to BuChE. Therefore, the inhibitory activities of 5-aminobenzimidazolone derivatives to acetylcholinesterase are worth further researching.
Asunto(s)
Texto completo: 1 Índice: WPRIM Asunto principal: Acetilcolinesterasa / Relación Estructura-Actividad / Bencimidazoles / Diseño de Fármacos / Química / Inhibidores de la Colinesterasa / Fenilcarbamatos / Rivastigmina / Metabolismo Idioma: Zh Revista: Acta Pharmaceutica Sinica Año: 2015 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Acetilcolinesterasa / Relación Estructura-Actividad / Bencimidazoles / Diseño de Fármacos / Química / Inhibidores de la Colinesterasa / Fenilcarbamatos / Rivastigmina / Metabolismo Idioma: Zh Revista: Acta Pharmaceutica Sinica Año: 2015 Tipo del documento: Article