Effect of ethyl gallate on invasion abilities and its mechanism of breast cancer MDA-MB-231 cells / 药学学报
Acta Pharmaceutica Sinica
;
(12): 45-49, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-251819
ABSTRACT
This study is to investigate the effect of ethyl gallate on invasion capabilities and its mechanism of breast cancer MDA-MB-231 cells. Using cell adhesion and transwell assay, separately, the effects of ethyl gallate on the invasion of MDA-MB-231 cells were measured. The Akt-NF-κB signal pathway protein expressions were analyzed with Western blot. Also, the mRNA levels of MMP-9 and MMP-2 were analyzed by RT-PCR. Ethyl gallate inhibited the abilities of motility, adhesion and invasion of breast cancer MDA-MB-231 cells in vitro (P<0.05), inhibited the mRNA levels of MMP-9, MMP-2, phosphorylation of AKt and protein expression of NF-κB. It is concluded that ethyl gallate can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Fosforilación
/
Neoplasias de la Mama
/
ARN Mensajero
/
Transducción de Señal
/
Adhesión Celular
/
Movimiento Celular
/
FN-kappa B
/
Metaloproteinasa 2 de la Matriz
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
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