Histone deacetylase 6: structure, functions and development of selective inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 7-14, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-251825
ABSTRACT
Histone deacetylase 6 (HDAC6) is an unique subtype of histone deacetylases with two tandem deacetylase domains and substrate specificity for non-histone proteins. It is involved in many important physiological and pathological processes and has become a promising therapeutic target in recent decades. Different kinds of potent HDAC6-selective inhibitors have been reported around the world. This paper reviews the progress in the study of structure and functions of HDAC6 as well as the development of HDAC6-selective inhibitors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Especificidad por Sustrato
/
Química
/
Inhibidores de Histona Desacetilasas
/
Histona Desacetilasas
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
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