A model-based meta-analysis to compare urate-lowering response rate of febuxostat and allopurinol in gout patient / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1674-1683, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-251837
ABSTRACT
This study aims to compare the urate-lowering response rate of febuxostat and allopurinol in gout patient using a model-based meta-analysis. The literature search identified 22 clinical trials of gout with a total of 43 unique treatment arms that met our inclusion criteria, and a total of 6 365 gout patients were included in the study. The response rates of allopuriol and febuxostat were characterized by Tmax model and Emax model respectively, and the effect of baseline serum uric acid (sUA) and patient type on the drug effect was tested. The results showed that allopurinol can reach an average maximum response rate of 50.8% while febuxostat can reach a 100% response rate within a very short time, and the ED50 was 34.3 mg. Covariate analysis revealed that baseline sUA has a negative effect on response rate of allopurinol, and a positive effect on the predicted ED50 of febuxostat. For patients who had shown inadequate response to prior allopurinol treatment, the average response rate was about half that of the allopurinol responder patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tiazoles
/
Ácido Úrico
/
Sangre
/
Alopurinol
/
Supresores de la Gota
/
Usos Terapéuticos
/
Quimioterapia
/
Febuxostat
/
Gota
Tipo de estudio:
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS