Effects of pingyu capsule on signal transduction of rats with chronic stress-induced depression / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1743-1746, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-252231
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Pingyu capsule on such important regulatory factors as cAMP, PKA and PKC of the signal transduction in rats with chronic stress-induced depression.</p><p><b>METHOD</b>Wistar male rats were randomly divided into control group, model group, paroxetine group, and Pingyu capsule low, middle and high doses groups; rats in all groups but the control group were fed in single cage for 21 days and were given such irritations as lightening stroke on pelma, ice water swimming, pyretic fumigation and tail clipping during this period; lobe cortex and hippocampus of all rats were taken out for detection of the cAMP content by means of radioactive immunization, PKA and PKC content by Elisa, and the PKA and PKC activity by radioactive isotope.</p><p><b>RESULT</b>Content of cAMP in lobe cortex and hippocampus, content and activity of PKA in hippocampus, and content of PKC in lobe cortex of rats in the model group were lower than those in the normal group. Pingyu capsule and paroxetine can increase them.</p><p><b>CONCLUSION</b>The anti-depression effect of Pingyu capsule maybe related to its function of adjusting the signal transduction of cAMP-PKA.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Proteína Quinasa C
/
Ensayo de Inmunoadsorción Enzimática
/
Cápsulas
/
Radioinmunoensayo
/
Medicamentos Herbarios Chinos
/
Transducción de Señal
/
Ratas Wistar
/
Proteínas Quinasas Dependientes de AMP Cíclico
/
AMP Cíclico
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Artículo
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