Imatinib mesylate STI571 therapy for five patients with advanced gastrointestinal stromal tumors / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 129-131, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-252454
ABSTRACT
<p><b>OBJECTIVE</b>To explore the therapeutic effect of STI571(imatinib mesylate) on advanced gastrointestinal stromal tumors (GISTs).</p><p><b>METHODS</b>Clinical data of 5 cases with advanced GISTs were analyzed retrospectively.</p><p><b>RESULTS</b>The expression of c- kit (CD117) was detected by immunohistochemical method in five patients with advanced GISTs . All patients failed to systematic chemotherapy or radiofrequency and operation because of extensive and multiple metastases (4 cases underwent 1 to 3 times of exploratory surgery). Tumor size was markedly decreased one to six months after STI571 given without serious drug- related side effects.</p><p><b>CONCLUSIONS</b>STI571 is an effective chemotherapy for advanced unresectable or metastatic GISTs. Inhibitor of the Kit signal- transduction pathway is a promising regimen that is different from conventional chemotherapy for advanced GISTs.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Piperazinas
/
Pirimidinas
/
Benzamidas
/
Estudios Retrospectivos
/
Proteínas Proto-Oncogénicas c-kit
/
Usos Terapéuticos
/
Tumores del Estroma Gastrointestinal
/
Quimioterapia
/
Mesilato de Imatinib
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2005
Tipo del documento:
Artículo
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