Study of the correlation between the colorectal cancer Chinese medicine syndrome types and (excision repair cross-complementing 1, ERCC1) gene polymorphisms / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 628-632, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-252546
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between excision repair cross-complementing 1 (ERCC1) C8092A and C19007T gene polymorphisms and different Chinese medicine (CM) syndrome types of colorectal cancer (CC).</p><p><b>METHODS</b>Ninety-nine patients with CC were syndrome typed as dampness-heat accumulation syndrome, qi stagnation with blood stasis syndrome, Pi-Shen yang deficiency syndrome, and Gan-Shen yin deficiency syndrome. The gene polymorphisms of excision repair cross-complementing 1 (ERCC1) C8092A and C19007T in different CM syndrome types of CC were examined by polymorphisms chain reaction amplification and direct sequencing, and analyzed statistically.</p><p><b>RESULTS</b>The frequencies of C8092A genotype and allele in different CM syndrome types had no statistical difference (P > 0.05). The frequencies of C19007T genotype and allele in different CM syndrome types had statistical difference (P < 0.05). Of them, there was no statistical difference in the frequencies between dampness-heat accumulation syndrome and qi stagnation with blood stasis syndrome, or between Pi-Shen yang deficiency syndrome and Gan-Shen yin deficiency syndrome (P > 0.05). There was statistical difference between dampness-heat accumulation syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05). There was statistical difference between qi stagnation with blood stasis syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05).</p><p><b>CONCLUSION</b>ERCC1 C19007T gene polymorphisms might be associated with CM syndrome types of CC, which needed to be further studied.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Neoplasias Colorrectales
/
Deficiencia Yin
/
Deficiencia Yang
/
Diagnóstico
/
Proteínas de Unión al ADN
/
Endonucleasas
/
Genética
/
Genotipo
/
Medicina Tradicional China
Tipo de estudio:
Estudio diagnóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2012
Tipo del documento:
Artículo
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