Respiratory syncytial virus infection enhances airway hyperresponsiveness in guinea pigs and the underlined mechanism / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To study the relation between Respiratory Syncytial Virus infection and asthma development by measuring airway responsiveness (AR) and M2R function.</p><p><b>METHODS</b>Guinea pigs (n = 34) were randomly divided into 4 groups Hep-2/NS group (group A, n = 9), RSV/NS group (group B, n =9), Hep-2/OVA group (group C, n = 8) and RSV/OVA group(group D, n = 8). On day 21 after infection we tested AR and M2R. Then counted eosinophils in BALF and observed pathological change.</p><p><b>RESULTS</b>Intraairway pressure(IP mmH20) of group B had no significant difference with group A(P > 0.01), and the extent of IP decrease also had no difference between groups A and B (P > 0. 05), but IP of C group were much higher than group A (P<0.05), with extent of IP decrease lower than group A (P < 0.05). And IP of group D were higher than group C (P < 0.01), with the extent of IP decrease much lower than group C (P < 0.05).</p><p><b>CONCLUSION</b>RSV infection could enhance OVA-induced M2R dysfunction, then develop AHR.</p>