The effect of chronic intermittent hypoxia on p38MAPK in cerebral tissues of weanling rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 45-48, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-252713
ABSTRACT
<p><b>AIM</b>To study the effect of chronic intermittent hypoxia on p38MAPK in partial cerebral tissues of weanling rats.</p><p><b>METHODS</b>Randomly, fifty male SD rats (3-week-old-4-week-old) were divided into five groups 2-week-CIH group (2IH), 4-week-CIH group (4IH), 4-week-recovery group (4F), 2-week-control group (2C) and 4-week-control group (4C). Intermittent hypoxia model was induced by an intermittent hypoxia cabin. The expression of p38MAPK mRNA and the phosphorylation levels of p38MAPK (p-p38 protein) in the hippocampus and prefrontal cortex were measured by RT-PCR or Western blot respectively.</p><p><b>RESULTS</b>No matter in the hippocampus, or in the prefrontal cortex, the expression of p38MAPK mRNA and p-p38 protein in 2IH, 4IH and 4F groups were respectively higher than 2C and 4C groups (P < 0.05, respectively).</p><p><b>CONCLUSION</b>Chronic intermittent hypoxia can activate the p38MAPK in partial cerebral tissues of weanling rats.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Síndromes de la Apnea del Sueño
/
ARN Mensajero
/
Ratas Sprague-Dawley
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Corteza Prefrontal
/
Proteínas Quinasas p38 Activadas por Mitógenos
/
Genética
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Hipocampo
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Hipoxia
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Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2009
Tipo del documento:
Artículo
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