The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 475-478, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-252736
ABSTRACT
<p><b>AIM</b>To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.</p><p><b>METHODS</b>SD rats were divided into three groups Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.</p><p><b>RESULTS</b>There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.</p><p><b>CONCLUSION</b>Ang-(1-7) can relieve the renal process of diabetic rats.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fragmentos de Péptidos
/
Farmacología
/
Factor de Crecimiento Derivado de Plaquetas
/
ARN Mensajero
/
Angiotensina I
/
Ratas Sprague-Dawley
/
Diabetes Mellitus Experimental
/
Nefropatías Diabéticas
/
Factor de Crecimiento Transformador beta1
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2008
Tipo del documento:
Artículo
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