Expressions of transforming growth factor-beta(1) and Smad4 in rat models of chronic nonbacterial prostatitis and their clinical significance / 中华男科学杂志
National Journal of Andrology
;
(12): 490-494, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-252797
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of transforming growth factor-beta(1) and Smad4 in the prostatic tissue of rat models of chronic nonbacterial prostatitis (CNP), and to explore the mechanisms of CNP and its fibrosis.</p><p><b>METHODS</b>Sixty 6-month-old SD rats were randomly allocated into three groups of equal number normal control, 30 d CNP model and 45 d CNP model, the models made by castration + high-dose intramuscular injection of estradiol benzoate. The expressions of TGF-beta1 and Smad4 in the prostatic tissue were detected by immunohistochemistry and Western blot.</p><p><b>RESULTS</b>Compared with the normal controls, the 30 d and 45 d CNP rat models showed a significantly increased expression of TGF-beta1 and decreased expression of Smad4 (P < 0.05), even more significantly in the 45 d than in the 30 d group. And the expression of TGF-beta1 was negatively correlated with that of Smad4 in the CNP rat models.</p><p><b>CONCLUSION</b>TGF-beta1 and Smad4 may be involved in the pathogenesis of CNP, and prostatic fibrosis may make the condition difficult to cure.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Próstata
/
Prostatitis
/
Ratas Sprague-Dawley
/
Modelos Animales de Enfermedad
/
Proteína Smad4
/
Factor de Crecimiento Transformador beta1
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2010
Tipo del documento:
Artículo
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