Study on synergic and decreasing toxic effects of mineral water and Chinese herbal compound preparation on cisplatin / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1358-1361, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-252908
ABSTRACT
<p><b>OBJECTIVE</b>The synergic and decreasing toxic effects of mineral water and Chinese herbal compound preparation (MWCHCP) on cisplatin were investigated in sarcoma 180 (S180) mice.</p><p><b>METHOD</b>The S180 mice were treated for 5 days with intraperitoneal injection of cisplatin(7.33 mg x kg(-1)) and oral administration of MWCHCP(1 925, 3 850, 7 700 mg x kg(-1)). Then the mice were killed and the tumor growth inhibition rate, organ index, diarrhea index were determined. Observe pathological sections of stomach to study the protective effect of MWCHCP. Reverse transcription-polymerase chain reaction (RT-PCR) was applied to investigate the tumour necrosis factor-alpha (TNF-alpha) expression level of the intestine.</p><p><b>RESULT</b>Combining with cisplatin and MWCHCP caused a tendency of increasing the tumor growth inhibition rate and significant attenution of cisplatin-induced diarrhea, visceral organ injury, gastric mucosal injury and decreased TNF-alpha mRNA level of intestine.</p><p><b>CONCLUSION</b>The present findings suggest that MWCHCP increases the inhibition rate of tumor growth of cisplatin and has a beneficial influence on gastrointestinal lesion induced by cisplatin.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Sarcoma 180
/
Medicamentos Herbarios Chinos
/
Cisplatino
/
Modelos Animales de Enfermedad
/
Sinergismo Farmacológico
/
Quimioterapia
/
Quimioterapia Combinada
/
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
/
Aguas Minerales
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2011
Tipo del documento:
Artículo
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