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Fucoidan by inhibiting cathepsin D activities alleviates PC12 apoptosis induced by hydrogen peroxide / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1083-1086, 2011.
Artículo en Chino | WPRIM | ID: wpr-252936
ABSTRACT
Cathepisn D plays a key role in early process of apoptosis before mitochondrion damage and caspases activations, and also involves in Alzheimer's disease (AD). Glycosaminoglycans (GAGs) have been suggested to inhibit the progress of apoptosis. Fucoidan, a nature GAGs mimetic, is shown as a potential candidate for neuroregressive disease. Here we reported PC12 cells response to oxidative stress with clear cathepsin D release, followed by caspase-3 activation. We found that fucoidan treatment can alleviate cathepsin D and caspase-3 activation, and improve cell survival. Furthermore, for the first time, fucoidan was shown to directly inhibit human liver cathepsin D by a dose-dependent way. These results support that cathepsin D involves in early apoptosis, suggest that fucoidan can decrease apoptosis at lysosome-cathepsin D level, which opens a new therapeutic approach to AD.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Polisacáridos / Supervivencia Celular / Catepsina D / Células PC12 / Apoptosis / Estrés Oxidativo / Línea Celular Tumoral / Quimioterapia / Caspasa 3 Límite: Animales / Humanos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Polisacáridos / Supervivencia Celular / Catepsina D / Células PC12 / Apoptosis / Estrés Oxidativo / Línea Celular Tumoral / Quimioterapia / Caspasa 3 Límite: Animales / Humanos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2011 Tipo del documento: Artículo