Protective role of endogenous carbon monoxide to lung and kidney tissues during septic shock / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 92-96, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-253077
ABSTRACT
<p><b>AIM</b>To study the protective role of endogenous carbon monoxide to lung and kidney tissues during septic shock and its mechanism.</p><p><b>METHODS</b>A rat model of CLP was built by using the method of CLP. The malondialdehyde (MDA) content and the activity of superoxide dematase (SOD) in blood, lung and kidney were detected by immunohistochemical technique and light microscope.</p><p><b>RESULTS</b>Pathological changes of lung and kidney in CLP + Hemin group were lighter than CLP group, inflammatory reaction and lipid peroxidation were also lighter.</p><p><b>CONCLUSION</b>Endogenous CO can protect lung and kidney from the oxidative injury. It can suppress in flammation and the oxidative injury caused by activated inflammatory cells, it is probably an important mechanism of its protective effects.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Fisiología
/
Choque Séptico
/
Superóxido Dismutasa
/
Monóxido de Carbono
/
Peroxidación de Lípido
/
Ratas Sprague-Dawley
/
Hemina
/
Riñón
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2007
Tipo del documento:
Artículo
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