Effect and possible mechanism of melatonin on the firing rate of pain neurons in lateral habenular nucleus / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 322-325, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-253154
ABSTRACT
<p><b>AIM</b>The effect and possible mechanism of Melatonin (MEL) on firing rate of pain neurons in lateral habenular nucleus of rats were investigated in the experiment.</p><p><b>METHODS</b>Single extracellular firing were recorded to study the firing rate changes of pain neurons and sensitivity changes to pain stimulation induced by MEL in LHb of rats. Reverse effect of naloxone on the analgesia induced by melatonin was also observed.</p><p><b>RESULTS</b>Melatonin showed the effects on the firing of pain neurons in the LHb and decreased the sensitivity of pain neurons to pain stimulation, which could be reversed by naloxone.</p><p><b>CONCLUSION</b>Melatonin can change the responses of pain neurons to pain stimulation via opioid receptor in the LHb, which might be one of analgesic mechanisms by MEL.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Ratas Wistar
/
Habénula
/
Analgésicos
/
Melatonina
/
Neuralgia
/
Neuronas
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2006
Tipo del documento:
Artículo
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