Recent advances in research on granulocyte colony-stimulating factor--review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 452-456, 2008.
Article
en Zh
| WPRIM
| ID: wpr-253299
Biblioteca responsable:
WPRO
ABSTRACT
Granulocyte colony-stimulating factor (G-CSF) is a kind of hematopoietic growth factor which is produced by monocytes, fibroblasts and endothelial cells. G-CSF acts on neutrophilic progenitor cells by binding to specific cell surface receptors, thereby stimulates proliferation, differentiation, commitment, and selected end-cell functional activation including enhanced phagocytic ability, priming of the cellular metabolism associated with respiratory burst, antibody dependent killing and the increased expression of some functions associated with cell surface antigens. G-CSF is effective and safe for treatment of neutropenia. In this paper, structure of G-CSF and its mechanism, recent status of research on G-CSF, pharmacokinetics, clinical application, adverse effects and prospect of G-CSF are mainly reviewed.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Farmacocinética
/
Factor Estimulante de Colonias de Granulocitos
/
Usos Terapéuticos
/
Hematopoyesis
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2008
Tipo del documento:
Article