An update on beta2 integrin LFA-1 and ligand ICAM-1 signaling / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 213-216, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-253348
ABSTRACT
LFA-1 and ICAM-1 mediate a bi-directional signaling across the cell membrane which is essential for biological functions of lymphocyte, including exudation, activation, adhesion, immunosurveillance as well as immuno-logical synapse formation. The signal transducing is a dynamic process and dependent on the binding capacity between LFA-1 and ICAM-1. The affinity and the avidity of LFA-1 are two major regulation forms in this process. Phosphorylation of LFA-1 and cytoskeleton protein talin 1 play a critical role in signal transducing. In biology of lymphocyte, LFA-1 and ICAM-1 interaction forms the co-stimulatory signal to promote activation, proliferation and division. In this article the regulation of binding capacity between LFA-1 and ICAM-1, the regulation of LFA-1 subunit phosphorylation, the role of talin1 in signaling transduction of LFA-1 and ICAM-1, the synergic stimulatory signaling of LPA-1 and ICAM-1 were reviewed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fosforilación
/
Fisiología
/
Linfocitos
/
Transducción de Señal
/
Antígeno-1 Asociado a Función de Linfocito
/
Talina
/
Molécula 1 de Adhesión Intercelular
/
Biología Celular
/
Alergia e Inmunología
/
Ligandos
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2008
Tipo del documento:
Artículo
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