Changes of glycine uptake of synaptosomes of rat spinal cord in 0.7 MPa (7ATA) air pressure / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To study changes of function of transmitter glycine in nitrogen narcosis.</p><p><b>METHODS</b>Synaptosomes of rat spinal cord were prepared. Glycine uptake of synaptosomes of rat spinal cord in 0.7 MPa (7ATA) hyperbaric air pressure was observed by the methods of isotope.</p><p><b>RESULTS</b>Glycine uptake slowed down and took a longer period of time to reach saturation in 0.7 MPa (7ATA). The maximum glycine uptake was lessened. Vm was diminished, but Km was increased. Vm rose in 0.7 MPa (7ATA) when corticosterone was added.</p><p><b>CONCLUSION</b>When nitrogen narcosis arose in 0.7 MPa (7ATA), the function of transporters of glycine re-uptake was reduced, the affinity of glycine for transporters subsided. Corticosterone was conductive to the recovery of the function of glycine transporters of high affinity.</p>