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Feasibility and Efficacy of Stereotactic Ablative Radiotherapy for Barcelona Clinic Liver Cancer-C Stage Hepatocellular Carcinoma
Journal of Korean Medical Science ; : 213-219, 2013.
Artículo en Inglés | WPRIM | ID: wpr-25355
ABSTRACT
The purpose of this study was to assess the feasibility and efficacy of stereotactic ablative radiotherapy (SABR) for liver tumor in patients with Barcelona Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma (HCC). We retrospectively reviewed the medical records of 35 patients between 2003 and 2011. Vascular invasion was diagnosed in 32 patients, extrahepatic metastases in 11 and both in 8. Thirty-two patients were categorized under Child-Pugh (CP) class A and 3 patients with CP class B. The median SABR dose was 45 Gy (range, 30-60 Gy) in 3-5 fractions. The median survival time was 14 months. The 1- and 3-yr overall survival (OS) rate was 52% and 21%, respectively. On univariate analysis, CP class A and biologically equivalent dose > or = 80 Gy10 were significant determinants of better OS. Severe toxicity above grade 3, requiring prompt therapeutic intervention, was observed in 5 patients. In conclusion, SABR for BCLC-C stage HCC showed 1-yr OS rate of 52% but treatment related toxicity was moderate. We suggest that patients with CP class A are the best candidate and at least SABR dose of 80 Gy10 is required for BCLC-C stage.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Dosis de Radiación / Índice de Severidad de la Enfermedad / Estudios de Factibilidad / Tasa de Supervivencia / Estudios Retrospectivos / Estudios de Seguimiento / Técnicas Estereotáxicas / Fallo Hepático / Carcinoma Hepatocelular Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Dosis de Radiación / Índice de Severidad de la Enfermedad / Estudios de Factibilidad / Tasa de Supervivencia / Estudios Retrospectivos / Estudios de Seguimiento / Técnicas Estereotáxicas / Fallo Hepático / Carcinoma Hepatocelular Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2013 Tipo del documento: Artículo