Design and synthesis of quinoxaline derivatives and their antitumor activities / 药学学报

ABSTRACT

<p><b>AIM</b>To design and synthesize novel quinoxaline derivatives as antitumor agents.</p><p><b>METHODS</b>Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.</p><p><b>RESULTS</b>The structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR.</p><p><b>CONCLUSION</b>At concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.</p>