Preparation of silymarin proliposomes and its pharmacokinetics in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 758-763, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-253573
ABSTRACT
<p><b>AIM</b>To study the preparation of silymarin proliposomes. To study its physicochemic properties, its pharmacokinetical characteristics and bioavailability in rats after oral administration.</p><p><b>METHODS</b>Silymarin proliposomes were prepared by film-deposition on carriers. When the proliposomes were contacted with water to form liposome suspensions, the tests of physicochemical properties including encapsulation efficiency, particle size and stability of the formed liposome suspensions were determined by HPLC, laser-particle-sizer and etc. The concentrations of non-conjugated and overall silymarin in plasma of rats and their pharmacokinetic behaviors after oral administration were studied by RP-HPLC. The pharmacokinetic parameters were computed by software program 3P97.</p><p><b>RESULTS</b>The encapsulation efficiency of silymarin liposomes could be more than 90%, with an average particle size of about 238.8 nm and a very good stability. The high bioavailability of silymarin proliposomes could be gotten by oral administration.</p><p><b>CONCLUSION</b>Compared with silymarin, silymarin proliposome is a stable and easily industrialized preparation and did enchance the gastrointestinal absorption of silymarin.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de la Partícula
/
Plantas Medicinales
/
Silimarina
/
Sangre
/
Portadores de Fármacos
/
Farmacocinética
/
Disponibilidad Biológica
/
Química
/
Administración Oral
/
Tecnología Farmacéutica
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2005
Tipo del documento:
Artículo
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