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Effects of electroacupuncture on hippocampal nNOS expression in rats of post-traumatic stress disorder model / 中国针灸
Chinese Acupuncture & Moxibustion ; (12): 632-636, 2013.
Artículo en Chino | WPRIM | ID: wpr-253932
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of electroacupuncture (EA) in the treatment of post-traumatic stress disorder (PTSD).</p><p><b>METHODS</b>Thirty male Sprague-Dawley rats were randomly divided into a normal group, a model group and an electroacupuncture group. The single prolonged stress (SPS) method was used to set up the PTSD models in latter two groups. After SPS Stimulation, EA group was treated with 2Hz electroacupuncture at Baihui (GV 20) and Zusanli (ST 36) for 30 min, once a day for a week. Reverse transcriptase polymerase chain reaction (RT-PCR) and immuno-histochemistry were used to detect the mRNA and protein expression of nNOS in the hippocampus of rats in the each group.</p><p><b>RESULTS</b>(1) The nNOS mRNA expression in hippocampus in model group was higher than that in normal group (P < 0.05). But the expression in EA group was lower significantly than that in model group (P < 0.05). (2) The nNOS protein expression in hippocampus CA1 and CA3 in model group was higher than that in normal group (P < 0.05). But after electroacupuncture treatment, its expression in EA group was lower significantly than that in model group (P < 0.05). The nNOS protein expression in hippocampal CA2 had no difference among all three groups.</p><p><b>CONCLUSION</b>The elevated nNOS expression in hippocampus may be involved in the pathological process of PTSD. Electroacupuncture play a down-regulation effects in the hippocampal nNOS expression, which may be one mechanism of electroacupuncture for treatment of PTSD.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trastornos por Estrés Postraumático / Terapéutica / Electroacupuntura / Ratas Sprague-Dawley / Óxido Nítrico Sintasa de Tipo I / Genética / Hipocampo / Metabolismo Límite: Animales / Humanos / Masculino Idioma: Chino Revista: Chinese Acupuncture & Moxibustion Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trastornos por Estrés Postraumático / Terapéutica / Electroacupuntura / Ratas Sprague-Dawley / Óxido Nítrico Sintasa de Tipo I / Genética / Hipocampo / Metabolismo Límite: Animales / Humanos / Masculino Idioma: Chino Revista: Chinese Acupuncture & Moxibustion Año: 2013 Tipo del documento: Artículo