Relationship between heparanase mRNA expression in human gastric cancer and its clinicopathological features / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 609-611, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-254274
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between heparanase mRNA expression and clinicopathological parameters in human gastric cancer.</p><p><b>METHODS</b>RT-PCR was used to detect the expression of heparanase mRNA in 43 human gastric carcinomas and 10 adjacent normal gastric tissues.</p><p><b>RESULTS</b>Heparanase mRNA was expressed in 29 of the 43 cases of gastric cancer with a positive rate of 67.4%, which was significantly higher than that in adjacent normal gastric tissues (P = 0.013). The expression level was higher in late-stage tumors (stage III and IV) than in early-stage tumors (stage I and II) (P = 0.001), in tumors with invasion to serosa than those without serosal invasion (P = 0.009), in tumors with lymph node metastasis than those without lymph node metastasis (P = 0.018), and in large-sized tumors than in small-sized ones (P = 0.009). The expression was not correlated with patients' age, sex, tumor location, histologic types, differentiation, peritoneal dissemination and liver metastasis (P > 0.05).</p><p><b>CONCLUSION</b>Heparanase might play an important role in the development of invasion and metastasis of gastric cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias Gástricas
/
ARN Mensajero
/
Adenocarcinoma
/
Genética
/
Glucuronidasa
/
Neoplasias Hepáticas
/
Ganglios Linfáticos
/
Metástasis Linfática
/
Metabolismo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2004
Tipo del documento:
Artículo
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