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Safety and efficacy of intraperitoneal hyperthermic perfusion chemotherapy following laparoscopic palliative resection for gastric cancer patients with peritoneal metastasis / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 1087-1091, 2014.
Artículo en Chino | WPRIM | ID: wpr-254357
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the safety and efficacy of postoperative intraperitoneal hyperthermic perfusion chemotherapy(IHPEC) following laparoscopic palliative resection for advanced gastric cancer patients with peritoneal metastasis.</p><p><b>METHODS</b>Between March 2010 and October 2013, 37 patients with advanced gastric cancer were treated by IHPEC(cisplatin 100 mg, 5-fluorouracil 1000 mg and saline 2000 mL) following laparoscopic palliative resection in our department between March 2010 and October 2013 were analyzed retrospectively. Short-term efficacy and adverse reactions were observed.</p><p><b>RESULTS</b>Complete remission (CR), partial remission (PR), stable disease (SD) and progressive disease (PD) were found in 18, 4, 8 and 7 cases respectively, and the total progression-free rate was 59.5%(22/37). The significant improved, improved, stable and progressive cases of Karnofsky performance status were 6, 13, 10 and 8 respectively, and the rate of improved and stable cases was 78.4% (29/37). Serious adverse reactions (class III ( or IIII) were noted in 3 cases (8.1%), including 2 cases of abdominal pain (class III), 1 case of nausea and vomiting.</p><p><b>CONCLUSIONS</b>The modality of IHPEC adopting cisplatin plus 5-fluorouracil regimen following laparoscopic palliative resection for advanced gastric cancer patients with peritoneal metastasis is technically feasible and safe, which has certain effect on postponing the progression of gastric cancer.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cuidados Paliativos / Neoplasias Peritoneales / Neoplasias Gástricas / Cirugía General / Inducción de Remisión / Protocolos de Quimioterapia Combinada Antineoplásica / Estudios Retrospectivos / Cisplatino / Laparoscopía / Usos Terapéuticos Tipo de estudio: Estudio observacional Límite: Humanos Idioma: Chino Revista: Chinese Journal of Gastrointestinal Surgery Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cuidados Paliativos / Neoplasias Peritoneales / Neoplasias Gástricas / Cirugía General / Inducción de Remisión / Protocolos de Quimioterapia Combinada Antineoplásica / Estudios Retrospectivos / Cisplatino / Laparoscopía / Usos Terapéuticos Tipo de estudio: Estudio observacional Límite: Humanos Idioma: Chino Revista: Chinese Journal of Gastrointestinal Surgery Año: 2014 Tipo del documento: Artículo